Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes
نویسندگان
چکیده
منابع مشابه
Long Isoforms of NRF1 Contribute to Arsenic-Induced Antioxidant Response in Human Keratinocytes
BACKGROUND Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (ARE)-dependent genes. OBJECTIVES We investigated the role of NRF1 in arsenic-...
متن کاملCytotoxicity patterns of arsenic trioxide exposure on HaCaT keratinocytes
BACKGROUND Arsenic is a ubiquitous environmental toxicant, and abnormalities of the skin are the most common outcomes of long-term, low-dose, chronic arsenic exposure. If the balance between keratinocyte proliferation, differentiation, and death is perturbed, pathologic changes of the epidermis may result, including psoriasis, atopic dermatitis, and certain forms of ichthyosis. Therefore, resea...
متن کاملProtective Effects of Lindera coreana on UVB-induced Oxidative Stress in Human HaCaT Keratinocytes
The present study was designed to investigate the protective effect of ethanol extracts from Lindera coreana leaves (LCE) on UVB-induced oxidative stress in HaCaT keratinocytes. The HaCaT cells were pretreated with LCE for 24 h and then exposed to UVB (20 mJ/cm2) for 2 h. UVB significantly decreased the cell viability (p
متن کاملNrf1 to the rescue
When the level of proteasomal activity in a cell drops off, a transcription factor called Nrf1 travels to the nucleus to activate the genes that code for proteasomes.
متن کاملProtective Effects of Lindera coreana on UVB-induced Oxidative Stress in Human HaCaT Keratinocytes
The present study was designed to investigate the protective effect of ethanol extracts from Lindera coreana leaves (LCE) on UVB-induced oxidative stress in HaCaT keratinocytes. The HaCaT cells were pretreated with LCE for 24 h and then exposed to UVB (20 mJ/cm2) for 2 h. UVB significantly decreased the cell viability (p
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21062014